MHRP

Research Contributions

RV144 Vaccine Trial

Thai Study First to Show Some Effectiveness in Preventing HIV

An Army-sponsored phase III clinical trial (RV144) involving more than 16,000 adult volunteers in Thailand showed that an investigational HIV vaccine regimen was safe and modestly effective in preventing HIV infection.

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  • Identified heterosexual transmission of HIV-1
  • Characterized more than half of the known HIV genetic subtypes
  • Successfully integrated care and treatment with basic and clinical vaccine research
  • Led in the development of HIV vaccines for global deployment (non-B subtype)
  • Provided key insights into host genetics and immunopathogenesis
  • Developed MVA HIV vaccine candidate
  • Invented Transcutaneous Immunization (TCI) as a method of adjuvanted immunization by skin patch
  • Helped ensure safe blood supply for warfighter
  • Developed the initial HIV disease staging system

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News & Updates

MHRP International Network

Nigeria, Kenya, Tanzania, Uganda,
Thailand, U.S., Mozambique

Voices from the Field

Voices from the Field

MHRP Profiles: Ebola Vaccine Trial Participant


Jackson Otim Oyugi is a soft spoken and multi-talented gentleman. He is also is a first cousin to Dr. Mathew Lukwiya, the first medical officer to die in the line of duty during Uganda’s first Ebola outbreak in Gulu district in 2000. Jackson is participating in the first phase I Ebola/Marburg vaccine clinical trial on the African continent.

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In the Spotlight

Video: The African Cohort Study (AFRICOS)

An important new study will recruit 3,600 individuals in Africa to help researchers better understand what leads to the best clinical outcomes. Throughout this 15-year study, MHRP researchers will look at current national treatment regimens and long-term outcomes such as time to progression to AIDS and mortality, as well as non-infectious co-morbidities such as TB and malaria. Watch the video to learn more!

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HIV Diagnostics & Reference Laboratory

MHRP oversees all HIV testing for the Army and serves as the Tri-Service Reference Laboratory.

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