MHRP

Research

MHRP is a broad-based, highly collaborative, and highly integrated research program with strong epidemiology, preclinical and clinical research capabilities.

Since its inception in 1986, MHRP has developed five sites in Africa and Asia and its research has expanded in scope and diversity.

Current Studies

STUDY PROTOCOL TITLE STATUS
RV 142 HIV and Malaria Cohort Study Among Plantation Workers and Adult Dependents in Kericho, Kenya Data analysis
RV 143 Infectious Disease Surveillance (HIV, TB, and Malaria) and Cohort Development Among Urban and Rural Adults in Mbeya Municipality, Tanzania Data analysis
RV 144 A Phase III Trial of Aventis Pasteur Live Recombinant ALVAC-HIV (vCP1521) Priming with VaxGen gp120 B/E (AIDSVAX B/E) Boosting HIV-Uninfected Thai Adults (IND#8795) Completed
RV 152 Extended Evaluation of Virologic, Immunologic, and Clinical Course of Volunteers Who Become HIV-1 Infected in a Phase III Vaccine Trial of ALVAC and AIDSVAX/BE Completed
RV 158 A Phase I Double-Blind, Randomized Dose-Escalating, Placebo-Controlled, Study of Safety and Immunogenicity of WRAIR/NIH Live Recombinant MVA-CMDR (HIV-1 CM235 env/CM240 gag/pol) Administered by Intramuscular (IM) or Intradermal (ID) Route in HIV-Uninfected Adults Follow-up
RV 161 Seroepidemiologic Case-Control Study of HIV-1 Infected and Non-Infected U.S. Military Service Members Data analysis
RV 165 Epidemiology of HIV-1 in Panama Enrolling
RV 172 A Phase I/II Clinical Trial to Evaluate the Safety and Immunogenicity of a Multiclade HIV-1 DNA Plasmid Vaccine, VRC-HIVDNA016-00-VP, Boosted by a Multiclade HIV-1 Recombinant Adenovirus-5 Vector Vaccine, VRC-HIVADV014-00-VP, in HIV Uninfected Adult Volunteers in East Africa Follow-up
RV 179 Donors for In Vitro Research
Enrolling
RV 180 Nucleic Acid Assays for Diagnosis of HIV Infection in Anticipation of an HIV Vaccine: Sample Collection for Sensitivity and Specificity Analysis Enrolling
RV 186 (ACTG Study) Optimal Combination Therapy After Nevirapine Exposure (OCTANE) Follow-up
RV 217 HIV-1 Prevalence, Incidence, Cohort Retention, and Host Genetics and Viral Diversity in High-Risk Cohorts in East Africa and Thailand Enrolling
RV 229 Apheresis of Blood Components from Healthy Volunteers for In Vitro Research Enrolling
RV 230 Evaluation of Feasibility and Target Populations for HIV Vaccine Cohort Development in Nigeria Enrolling
RV 242 Genetic Subtypes and Antiretroviral Drug Resistance of HIV-1 in Romania Enrolling
RV 245 Knowledge, Attitude, and Practice and Seroprevalence Assessment of HIV, Syphilis, and Hepatitis B and C Among Afghan National Army Recruits in Afghanistan Enrolling
RV 246 A Cohort Observational Study Evaluating the Incidence and Immunopathogenesis of Immune Reconstitution Syndrome (IRIS) in HIV-1 Infected Patients With CD4 Count <100 Cells/µL Who Are Initiating Antiretroviral Therapy Data Analysis
RV 247 A Phase IB Study to Evaluate the Safety and Immunogenicity of an Ebola DNA Plasmid Vaccine, VRC-EBODNA023-00-VP, and a Marburg DNA Plasmid Vaccine, VRC-MARDNA025-00-VP, in Healthy Adults in Kampala, Uganda Data Analysis
RV 257 CLinic-based ART Diagnostic Evaluation (CLADE) Follow-up
RV 261 HIV-1 Surveillance of High-Risk Groups in Bulgaria Enrolling
RV 262 A Phase I Study of the Safety and Immunogenicity of Pennvax-G DNA (ENV & GAG) Administered By Intramuscular Biojector 2000 of Cellectra Intramuscular Electroporation Device Followed By MVA-CMDR (HIV-1 CM235 ENV/CM240 GAG/POL) Boost in Healthy, HIV Unifected Adults Enrolling
RV 269 Development of Novel Host Genetic, Virological, and Immune Assays for the Determination of Correlates of Protection in HIV Vaccine and HIV Natural History Studies Open
RV 271 Specimen Collection Procedures to Obtain Products for Clinical Laboratory Quality Management Practices - Uganda Enrolling
RV 274 Specimen Collection Procedures to Obtain Products for Clinical Laboratory Quality Management Practices - Thailand Enrolling
RV 277 Program Evaluation of Voluntary Medical Male Circumcision Roll-out Program in Kayunga District Enrolling
RV 279 Evaluation of Early Diagnosis of HIV in Infants Using the Polymerase Chain Reaction Method on Dry Blood Spots and Linkage of DBS Results to Care and Treatment in the Southern Highlands Zone in Tanzania Enrolling
RV 280 Prevalence, Clinical Features, and Clinical Outcome of Cryptococcal Meningitis Among HIV Positive Patients Admitted in Medical Wards at Mbeya Referral Hospital, 1st June 2006 to 31st May 2007 Enrolling
RV 281 Long-term sequelae and immune response to Ebola virus infection in Uganda
 Data Analysis
RV 283 Extended Follow-Up for Participants in VRC HIV Candidate Vaccine Studies in Uganda  
RV 288 A Virological Assessment of Walter Reed- Supported PEPFAR Program Participants on Antiretroviral Therapy Open
RV 295 (ACTG Study)
Optimal Combination Therapy After Nevirapine Exposure (OCTANE) – Eldoret CRS Follow-up
RV 298 (ACTG Study)
A5225 A Phase I/II Dose-Finding Study of High-Dose Fluconazole Treatment in AIDS-Associated Cryptococcal Meningitis
Open
RV 299 (ACTG Study)
A5225 A Phase I/II Dose Finding Study of High Dose Fluconazole treatment in AIDS Associated Cryptococcal Meningitis Open
RV 305 Randomized, Double Blind Evaluation of Late Boost Strategies for HIV-uninfected Participants in the HIV Vaccine Efficacy Trial RV144 Enrolling
RV 306 Randomized, Double Blind Evaluation of Aventis Pasteur Live Recombinant Alvac-HIV (vCP1521) Priming and Multiple Boosting Strategies with and without VAXGEN gp 120 B/E in HIV-Uninfected Thai Adults Enrolling
RV 315 Anaylsis of Antigen Specific HIV Immune Responses in Whole Blood Samples Open
RV 317 Pathogenic T cell activation in HIV-1 Chronic Infection from the Index Partner of Discordant Couples Initiating Antiretroviral therapy in Uganda Open
RV 325 A Phase III, Open Label, Randomized, Assessment-Blinded Clinical Trial to Compare the Safety and Efficacy of Tropical Gentian Violet to that of Nystain Oral Suspension for the Treatment of Oropharyneal Candidiasis in HIV-1 Infected Participants in Non U.S Settings Open
RV 327 A Phase III, Open Label, Randomized, Assessment-Bilinded Clinical Trial to Compare the Safety and Efficacy of Tropical Gentian Violet to that of Nystain Oral Suspension for the Treatment of Oropharyneal Candidiasis in HIV-1 Infected Participants in Non U.S Settings Open
RV 329 African Cohort Study Enrolling
RV 330 STI Prevalence and Associated Demographic and Behavioral Risk Factors Among Depolying US Navy and Marine Corps Military Personnel Open
RV 332 Knowledge, Attitude, and Practice and Seroprevalance Assessment of HIV, Syphillis, and Hepetitis B and C Among Afghan National Police and Recruits in Afghanistan Data Analysis
RV 333 Reducing Early Mortality and Early Morbidity by Empric Tuberculosis Treatment Regimens Enrolling
RV 334 An Open-Label, Proof of Concept, Randomized Trial Comparing a LPV/r-Based to an nNRTI-Based Antiretroviral Therapy Regimen for Clearance of Plasmodium falciparum Subclinical Parasitemia in HIV-infected Adults with CD4+ Counts >200 and <350 cells/mm3 Enrolling
RV 352 An Evaluation of HIV and Malaria Co-Infection in Two Nigerian Military Hopsitals Enrolling
RV 353 Estimating the Malaria Attack Rate and Transmission Resovoir in the United Republic of Tanzania Enrolling
RV 356 Use of Venipuncture and Finger Stick Whole Blood for Comparative Flow Cytometry Evaluation Open
RV 361 Epidemiology and Risk Factors for HIV Infection in the U.S Air Force Service Members, 1996-2011 Open
RV 363 Cohort Development to Assess the Incidence of HIV Infection, Retention Rate and Willingness of Adults to Participate in Future HIV Vaccine Trials in Mozambique Enrolling
RV 369 Multicenter Study of Options for Second-Line Effective Combination Therapy (SELECT) Open
RV 385 Performance Evaluation of the Bio-Rad Geenius HIV-1/2 Supplemental Assay Enrolling