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2019 Publications

Goh OQ, Colby DJ, Pinyakorn S, Sacdalan C, Kroon E, Chan P, Chomchey N, Kanaprach R, Prueksakaew P, Suttichom D, Trichavaroj R, Spudich S, Robb ML, Phanuphak P, Phanuphak N, Ananworanich J; RV254/SEARCH 010 Study Group. Switch to dolutegravir is well tolerated in Thais with HIV infection. J Int AIDS Soc. 2019 Jul;22(7):e25324. doi: 10.1002/jia2.25324. PMID: 31294931.

Stafford KA, Odafe SF, Lo J, Ibrahim R, Ehoche A, Niyang M, Aliyu GG, Gobir B, Onotu D, Oladipo A, Dalhatu I, Boyd AT, Ogorry O, Ismail L, Charurat M, Swaminathan M. Evaluation of the clinical outcomes of the Test and Treat strategy to implement Treat All in Nigeria: Results from the Nigeria Multi-Center ART Study. PLoS One. 2019 Jul 10;14(7):e0218555. doi: 10.1371/journal.pone.0218555. eCollection 2019. PMID: 31291273.

Rossenkhan R, Rolland M, Labuschagne JPL, Ferreira RC, Magaret CA, Carpp LN, Matsen Iv FA, Huang Y, Rudnicki EE, Zhang Y, Ndabambi N, Logan M, Holzman T, Abrahams MR, Anthony C, Tovanabutra S, Warth C, Botha G, Matten D, Nitayaphan S, Kibuuka H, Sawe FK, Chopera D, Eller LA, Travers S, Robb ML, Williamson C, Gilbert PB, Edlefsen PT. Combining Viral Genetics and Statistical Modeling to Improve HIV-1 Time-of-infection Estimation towards Enhanced Vaccine Efficacy Assessment. Viruses. 2019 Jul 3;11(7). pii: E607. doi: 10.3390/v11070607. PMID: 31277299.

Mousseau G, Aneja R, Clementz MA, Mediouni S, Lima NS, Haregot A, Kessing CF, Jablonski JA, Thenin-Houssier S, Nagarsheth N, Trautmann L, Valente ST. Resistance to the Tat Inhibitor Didehydro-Cortistatin A Is Mediated by Heightened Basal HIV-1 Transcription. MBio. 2019 Jul 2;10(4). pii: e01750-18. doi: 10.1128/mBio.01750-18. PMID: 31266880.

Meffert SM, Neylan TC, McCulloch CE, Maganga L, Adamu Y, Kiweewa F, Maswai J, Owuoth J, Polyak CS, Ake JA, Valcour VG. East African HIV care: depression and HIV outcomes. Glob Ment Health (Camb). 2019 May 31;6:e9. doi: 10.1017/gmh.2019.6. eCollection 2019. PMID: 31258923.

Harbertson J, De Vera K, Scott PT, Li Y, Shaffer RA, Michael NL, Hale BR. Longitudinal survey of condom use across a US Navy and Marine Corps shipboard deployment. BMJ Open. 2019 Jun 22;9(6):e028151. doi: 10.1136/bmjopen-2018-028151. PMID: 31230018.

Korencak M, Byrne M, Richter E, Schultz BT, Juszczak P, Ake JA, Ganesan A, Okulicz JF, Robb ML, de Los Reyes B, Winning S, Fandrey J, Burgess TH, Esser S, Michael NL, Agan BK, Streeck H. Effect of HIV infection and antiretroviral therapy on immune cellular functions. JCI Insight. 2019 Jun 20;4(12). pii: 126675. doi: 10.1172/jci.insight.126675. eCollection 2019 Jun 20. PMID: 31217351.

Manak MM, Jagodzinski LL, Shutt A, Malia JA, Leos M, Ouellette J, Akapirat S, Colby DL, Phanuphak N, Eller LA, Robb ML, de Souza M, Ananworanich J, Peel SA; RV254/SEARCH010 and the RV217 Study Teams. Decreased seroreactivity in individuals initiating antiretroviral therapy during acute HIV infection. J Clin Microbiol. 2019 Jun 19. pii: JCM.00757-19. doi: 10.1128/JCM.00757-19. [Epub ahead of print] PMID: 31217270.

Kulkarni S, Lied A, Kulkarni V, Rucevic M, Martin MP, Walker-Sperling V, Anderson SK, Ewy R, Singh S, Nguyen H, McLaren PJ, Viard M, Naranbhai V, Zou C, Lin Z, Gatanaga H, Oka S, Takiguchi M, Thio CL, Margolick J, Kirk GD, Goedert JJ, Hoots WK, Deeks SG, Haas DW, Michael N, Walker B, Le Gall S, Chowdhury FZ, Yu XG, Carrington M. CCR5AS lncRNA variation differentially regulates CCR5, influencing HIV disease outcome. Nat Immunol. 2019 Jul;20(7):824-834. doi: 10.1038/s41590-019-0406-1. Epub 2019 Jun 17. PMID: 31209403.

Wilson K, Beckett CG, Blaylock JM, Okulicz JF, Scott PT, Hakre S. Provider Knowledge Gaps in HIV PrEP Affect Practice Patterns in the US Navy. Mil Med. 2019 Jun 11. pii: usz131. doi: 10.1093/milmed/usz131. [Epub ahead of print] 
PMID: 31184703.

Chan P, Dumrongpisutikul N, Subra C, Colby DJ, Kroon E, Fletcher J, Sacdalan C, Phanuphak N, Valcour V, Ananworanich J, Trautmann L, Spudich S. Neurosyphilis during Acute HIV Infection: A CNS Immunologic and Virologic Characterization. J Acquir Immune Defic Syndr. 2019 May 28. doi: 10.1097/QAI.0000000000002114. [Epub ahead of print] No abstract available. PMID: 31180994.

Singh P, Bodycomb J, Travers B, Tatarkiewicz K, Travers S, Matyas GR, Beck Z. Particle size analyses of polydisperse liposome formulations with a novel multispectral advanced nanoparticle tracking technology. Int J Pharm. 2019 Jul 20;566:680-686. doi: 10.1016/j.ijpharm.2019.06.013. Epub 2019 Jun 6. PMID: 31176851.

Bai H, Li Y, Michael NL, Robb ML, Rolland M. The breadth of HIV-1 neutralizing antibodies depends on the conservation of key sites in their epitopes. PLoS Comput Biol. 2019 Jun 6;15(6):e1007056. doi: 10.1371/journal.pcbi.1007056. eCollection 2019 Jun. PMID: 31170145.

Cawlfield A, Genito CJ, Beck Z, Bergmann-Leitner ES, Bitzer AA, Soto K, Zou X, Hadiwidjojo SH, Gerbasi RV, Mullins AB, Noe A, Waters NC, Alving CR, Matyas GR, Dutta S. Safety, toxicity and immunogenicity of a malaria vaccine based on the circumsporozoite protein (FMP013) with the adjuvant army liposome formulation containing QS21 (ALFQ). Vaccine. 2019 Jun 27;37(29):3793-3803. doi: 10.1016/j.vaccine.2019.05.059. Epub 2019 May 28. PMID: 31151801.

Geraghty DE, Thorball CW, Fellay J, Thomas R. Effect of Fc Receptor Genetic Diversity on HIV-1 Disease Pathogenesis. Front Immunol. 2019 May 9;10:970. doi: 10.3389/fimmu.2019.00970. eCollection 2019. Review. PMID: 31143176.

Billings E, Heipertz RA, Varleva T, Sanders-Buell E, O'Sullivan AM, Bose M, Howell S, Kijak GH, Taskov H, Elenkov I, Nenova M, Popivanova N, Valenzuela AB, Myles O, Bautista CT, Robb ML, Michael NL, Kim JH, Scott PT, Tovanabutra S, Ake JA. HIV-1 genetic diversity and demographic characteristics in Bulgaria. PLoS One. 2019 May 28;14(5):e0217063. doi: 10.1371/journal.pone.0217063. eCollection 2019. PMID: 31136611.

Billings E, Kijak GH, Sanders-Buell E, Ndembi N, OʼSullivan AM, Adebajo S, Kokogho A, Milazzo M, Lombardi K, Baral S, Nowak R, Ramadhani H, Gramzinski R, Robb ML, Michael NL, Charurat ME, Ake J, Crowell TA, Tovanabutra S; MHRP Viral Sequencing Core and the TRUST/RV368 Study Group. New Subtype B Containing HIV-1 Circulating Recombinant of sub-Saharan Africa Origin in Nigerian Men Who Have Sex With Men. J Acquir Immune Defic Syndr. 2019 Aug 15;81(5):578-584. doi: 10.1097/QAI.0000000000002076. PMID: 31107298.

Nadai Y, Held K, Joseph S, Ahmed MIM, Hoffmann VS, Peterhoff D, Missanga M, Bauer A, Joachim A, Reimer U, Zerweck J, McCormack S, Cope AV, Tatoud R, Shattock RJ, Robb ML, Sandstroem EG, Hoelscher M, Maboko L, Bakari M, Kroidl A, Wagner R, Weber J, Pollakis G, Geldmacher C. Envelope-Specific Recognition Patterns of HIV Vaccine-Induced IgG Antibodies Are Linked to Immunogen Structure and Sequence. Front Immunol. 2019 Apr 24;10:717. doi: 10.3389/fimmu.2019.00717. eCollection 2019. PMID: 31105688.

Vasan S, Robb ML. Harnessing circulating microRNAs for early HIV diagnosis. Curr HIV/AIDS Rep. 2019 Jun;16(3):236-243. doi: 10.1007/s11904-019-00445-6. Review. PMID: 31062168.

Subra C, Trautmann L. Role of T Lymphocytes in HIV Neuropathogenesis. Curr HIV/AIDS Rep. 2019 Jun;16(3):236-243. doi: 10.1007/s11904-019-00445-6. Review. PMID: 31062168.

Ramakrishnan A, Schumack NM, Gariepy CL, Eggleston H, Nunez G, Espinoza N, Nieto M, Castillo R, Rojas J, McCoy AJ, Beck Z, Matyas GR, Alving CR, Guerry P, Poly F, Laird RM. Enhanced Immunogenicity and Protective Efficacy of a Campylobacter jejuni Conjugate Vaccine Coadministered with Liposomes Containing Monophosphoryl Lipid A and QS-21. mSphere. 2019 May 1;4(3). pii: e00101-19. doi: 10.1128/mSphere.00101-19. Erratum in: mSphere. 2019 May 22;4(3):. mSphere. 2019 Jun 26;4(3):. PMID: 31043512.

Wade BSC, Valcour VG, Puthanakit T, Saremi A, Gutman BA, Nir TM, Watson C, Aurpibul L, Kosalaraksa P, Ounchanum P, Kerr S, Dumrongpisutikul N, Visrutaratna P, Srinakarin J, Pothisri M, Narr KL, Thompson PM, Ananworanich J, Paul RH, Jahanshad N; PREDICT and Resilience Study Groups. Mapping abnormal subcortical neurodevelopment in a cohort of Thai children with HIV. Neuroimage Clin. 2019 Apr 2;23:101810. doi: 10.1016/j.nicl.2019.101810. [Epub ahead of print] PMID: 31029050.

Trinh HV, Gohain N, Pham PT, Hamlin C, Song H, Sanders-Buell E, Bose M, Eller LA, Tovanabutra S, Michael NL, Robb ML, Joyce MG, Rao M. Humoral Response to the HIV-1 Envelope V2 Region in a Thai Early Acute Infection Cohort. Cells. 2019 Apr 19;8(4). pii: E365. doi: 10.3390/cells8040365. PMID: 31010245.

Harbertson J, Scott PT, Lemus H, Michael NL, Hale BR. Cross-Sectional Study of Sexual Behavior, Alcohol Use, and Mental Health Conditions Associated With Sexually Transmitted Infections Among Deploying Shipboard US Military Personnel. Mil Med. 2019 Apr 20. pii: usz070. doi: 10.1093/milmed/usz070. [Epub ahead of print] PMID: 31004170.

Crowell TA, Colby DJ, Pinyakorn S, Sacdalan C, Pagliuzza A, Intasan J, Benjapornpong K, Tangnaree K, Chomchey N, Kroon E, de Souza MS, Tovanabutra S, Rolland M, Eller MA, Paquin-Proulx D, Bolton DL, Tokarev A, Thomas R, Takata H, Trautmann L, Krebs SJ, Modjarrad K, McDermott AB, Bailer RT, Doria-Rose N, Patel B, Gorelick RJ, Fullmer BA, Schuetz A, Grandin PV, O'Connell RJ, Ledgerwood JE, Graham BS, Tressler R, Mascola JR, Chomont N, Michael NL, Robb ML, Phanuphak N, Ananworanich J; RV397 Study Group. Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial. Lancet HIV. 2019 May;6(5):e297-e306. doi: 10.1016/S2352-3018(19)30053-0. Epub 2019 Apr 15. PMID: 31000477.

Rolland M. Editorial: HIV-1 transmission and phylogenetics. Curr Opin HIV AIDS. 2019 May;14(3):151-152. doi: 10.1097/COH.0000000000000546. PMID: 30946140.

Rolland M. HIV-1 phylogenetics and vaccines. Curr Opin HIV AIDS. 2019 May;14(3):227-232. doi: 10.1097/COH.0000000000000545. PMID: 30925535.

Kijak GH, Sanders-Buell E, Pham P, Harbolick EA, Oropeza C, O'Sullivan AM, Bose M, Beckett CG, Milazzo M, Robb ML, Peel SA, Scott PT, Michael NL, Armstrong AW, Kim JH, Brett-Major DM, Tovanabutra S. Next-generation sequencing of HIV-1 single genome amplicons. Biomol Detect Quantif. 2019 Mar 11;17:100080. doi: 10.1016/j.bdq.2019.01.002. eCollection 2019 Mar. PMID: 30923677.

Takata H, Kessing C, Sy A, Lima N, Sciumbata J, Mori L, Jones RB, Chomont N, Michael NL, Valente S, Trautmann L. Modeling HIV-1 latency using primary CD4+ T cells from HIV-1 infected ART suppressed individuals. J Virol. 2019 Mar 27. pii: JVI.02248-18. doi: 10.1128/JVI.02248-18. [Epub ahead of print] PMID: 30918072.

Juma DW, Muiruri P, Yuhas K, John-Stewart G, Ottichilo R, Waitumbi J, Singa B, Polyak C, Kamau E. The prevalence and antifolate drug resistance profiles of Plasmodium falciparum in study participants randomized to discontinue or continue cotrimoxazole prophylaxis. PLoS Negl Trop Dis. 2019 Mar 21;13(3):e0007223. doi: 10.1371/journal.pntd.0007223. eCollection 2019 Mar. PMID: 30897090. 

Julg B, Dee L, Ananworanich J, Barouch DH, Bar K, Caskey M, Colby DJ, Dawson L, Dong KL, Dubé K, Eron J, Frater J, Gandhi RT, Geleziunas R, Goulder P, Hanna GJ, Jefferys R, Johnston R, Kuritzkes D, Li JZ, Likhitwonnawut U, van Lunzen J, Martinez-Picado J, Miller V, Montaner LJ, Nixon DF, Palm D, Pantaleo G, Peay H, Persaud D, Salzwedel J, Salzwedel K, Schacker T, Sheikh V, Søgaard OS, Spudich S, Stephenson K, Sugarman J, Taylor J, Tebas P, Tiemessen CT, Tressler R, Weiss CD, Zheng L, Robb ML, Michael NL, Mellors JW, Deeks SG, Walker BD. Recommendations for analytical antiretroviral treatment interruptions in HIV research trials-report of a consensus meeting. Lancet HIV. 2019 Apr;6(4):e259-e268. doi: 10.1016/S2352-3018(19)30052-9. Epub 2019 Mar 15. Review. PMID: 30885693.

Krebs SJ, Kwon YD, Schramm CA, Law WH, Donofrio G, Zhou KH, Gift S, Dussupt V, Georgiev IS, Schätzle S, McDaniel JR, Lai YT, Sastry M, Zhang B, Jarosinski MC, Ransier A, Chenine AL, Asokan M, Bailer RT, Bose M, Cagigi A, Cale EM, Chuang GY, Darko S, Driscoll JI, Druz A, Gorman J, Laboune F, Louder MK, McKee K, Mendez L, Moody MA, O'Sullivan AM, Owen C, Peng D, Rawi R, Sanders-Buell E, Shen CH, Shiakolas AR, Stephens T, Tsybovsky Y, Tucker C, Verardi R, Wang K, Zhou J, Zhou T, Georgiou G, Alam SM, Haynes BF, Rolland M, Matyas GR, Polonis VR, McDermott AB, Douek DC, Shapiro L, Tovanabutra S, Michael NL, Mascola JR, Robb ML, Kwong PD, Doria-Rose NA. Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual. Immunity. 2019 Mar 19;50(3):677-691.e13. doi: 10.1016/j.immuni.2019.02.008. Epub 2019 Mar 12. PMID: 30876875.

Henderson GE, Waltz M, Meagher K, Cadigan RJ, Jupimai T, Isaacson S, Ormsby NQ, Colby DJ, Kroon E, Phanuphak N, Ananworanich J, Peay HL. Going off antiretroviral treatment in a closely monitored HIV "cure" trial: longitudinal assessments of acutely diagnosed trial participants and decliners. J Int AIDS Soc. 2019 Mar;22(3):e25260. doi: 10.1002/jia2.25260. PMID: 30869203. 

Maljkovic Berry I, Eyase F, Pollett S, Konongoi SL, Joyce MG, Figueroa K, Ofula V, Koka H, Koskei E, Nyunja A, Mancuso JD, Jarman RG, Sang R. Global Outbreaks and Origins of a Chikungunya Virus Variant Carrying Mutations Which May Increase Fitness for Aedes aegypti: Revelations from the 2016 Mandera, Kenya Outbreak. Am J Trop Med Hyg. 2019 Mar 11. doi: 10.4269/ajtmh.18-0980. [Epub ahead of print] PMID: 30860010.

Jagodzinski LL, Manak MM, Hack HR, Liu Y, Malia JA, Freeman J, Phanuphak N, de Souza M, Kroon ED, Colby DJ, Chomchey N, Lally MA, Michael NL, Ananworanich J, Peel SA; RV254 SEARCH010 Study Team. Impact of early antiretroviral therapy on detection of cell-associated HIV-1 nucleic acid in blood by the Roche COBAS TaqMan Test. J Clin Microbiol. 2019 Mar 6. pii: JCM.01922-18. doi: 10.1128/JCM.01922-18. [Epub ahead of print] PMID: 30842229.

Karch CP, Matyas GR, Burkhard P, Beck Z. Glycosylation of the HIV-1 Env V1V2 loop to form a native-like structure may not be essential with a nanoparticle vaccine. Future Virol. 2019 Feb;14(2):51-54. doi: 10.2217/fvl-2018-0174. Epub 2019 Jan 10. No abstract available. PMID: 30815025. 

Fourati S, Ribeiro SP, Blasco Tavares Pereira Lopes F, Talla A, Lefebvre F, Cameron M, Kaewkungwal J, Pitisuttithum P, Nitayaphan S, Rerks-Ngarm S, Kim JH, Thomas R, Gilbert PB, Tomaras GD, Koup RA, Michael NL, McElrath MJ, Gottardo R, Sékaly RP. Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine. Nat Commun. 2019 Feb 20;10(1):863. doi: 10.1038/s41467-019-08854-2. PMID: 30787294. 

Ananthaswamy N, Fang Q, AlSalmi W, Jain S, Chen Z, Klose T, Sun Y, Liu Y, Mahalingam M, Chand S, Tovanabutra S, Robb ML, Rossmann MG, Rao VB. A sequestered fusion peptide in the structure of an HIV-1 transmitted founder envelope trimer. Nat Commun. 2019 Feb 20;10(1):873. doi: 10.1038/s41467-019-08825-7. PMID: 30787293. 

Hsu DC, Mellors JW. Longitudinal changes in HIV DNA in HIV controllers: what do they mean? J Int AIDS Soc. 2019 Feb;22(2):e25254. doi: 10.1002/jia2.25254. No abstract available. PMID: 30768753. 

Zhou M, Humbert M, Mukhtar MM, Scinto HB, Vyas HK, Lakhashe SK, Byrareddy SN, Maurer G, Thorat S, Owuor J, Lai Z, Chen Y, Griffiths A, Chenine AL, Gumber S, Villinger F, Montefiori D, Ruprecht RM. Adaptation of an R5 Simian-human Immunodeficiency Virus Encoding an HIV Clade A Envelope With or Without Ablation of Adaptive Host Immunity: Differential Selection of Viral Mutants. J Virol. 2019 Feb 13. pii: JVI.02267-18. doi: 10.1128/JVI.02267-18. [Epub ahead of print] PMID: 30760566.

Kanekiyo M, Joyce MG, Gillespie RA, Gallagher JR, Andrews SF, Yassine HM, Wheatley AK, Fisher BE, Ambrozak DR, Creanga A, Leung K, Yang ES, Boyoglu-Barnum S, Georgiev IS, Tsybovsky Y, Prabhakaran MS, Andersen H, Kong WP, Baxa U, Zephir KL, Ledgerwood JE, Koup RA, Kwong PD, Harris AK, McDermott AB, Mascola JR, Graham BS. Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses. Nat Immunol. 2019 Mar;20(3):362-372. doi: 10.1038/s41590-018-0305-x. Epub 2019 Feb 11. PMID: 30742080.

Kiweewa F, Esber A, Musingye E, Reed D, Crowell TA, Cham F, Semwogerere M, Namagembe R, Nambuya A, Kafeero C, Tindikahwa A, Eller LA, Millard M, Gelderblom HC, Keshinro B, Adamu Y, Maswai J, Owuoth J, Sing'oei VC, Maganga L, Bahemana E, Khamadi S, Robb ML, Ake JA, Polyak CS, Kibuuka H. HIV virologic failure and its predictors among HIV-infected adults on antiretroviral therapy in the African Cohort Study. PLoS One. 2019 Feb 5;14(2):e0211344. doi: 10.1371/journal.pone.0211344. eCollection 2019. PMID: 30721233. 

Hellmuth J, Slike BM, Sacdalan C, Best J, Kroon E, Phanuphak N, Fletcher JLK, Prueksakaew P, Jagodzinski LL, Valcour V, Robb M, Ananworanich J, Allen IE, Krebs SJ, Spudich S; SEARCH 010/RV254 and SEARCH013/RV304 Study Groups. Very early ART initiation during acute HIV infection is associated with normalization of cerebrospinal fluid but not plasma markers of immune activation. J Infect Dis. 2019 Jan 21. doi: 10.1093/infdis/jiz030. [Epub ahead of print] PMID: 30668739.

Michaud J, Moss K, Licina D, Waldman R, Kamradt-Scott A, Bartee M, Lim M, Williamson J, Burkle F, Polyak CS, Thomson N, Heymann DL, Lillywhite L. Militaries and global health: peace, conflict, and disaster response. Lancet. 2019 Jan 19;393(10168):276-286. doi: 10.1016/S0140-6736(18)32838-1. Review. PMID: 30663597.