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WRAIR's HIV Diagnostics and Reference Laboratory (HDRL) serves as the final DoD authority for HIV infection status in the Army and is the military’s Tri-Service Reference Laboratory. The Branch conducts more than a million confirmatory HIV tests per year and determines HIV infection status classification for all Army personnel. 

The diagnostics team is a leader in defining operational parameters for HIV and related disease diagnosis and also establishes critical laboratory monitoring parameters utilized by Military Health Care Providers for therapeutic management of a wide variety of infectious diseases. The department also collaborates with MHRP to develop diagnostic tools that accurately discriminate HIV vaccine-induced sero-reactive (VISR) responses from those of HIV infection.