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PEPFAR Research

The Office of the U.S. Global AIDS Coordinator (OGAC) has outlined a plan of investment in innovation and operations research. The goal is to evaluate impact, improve service delivery and maximize outcomes with PEPFAR partners in Africa. MHRP’s collaboration between research and PEPFAR programs provides an excellent platform from which to implement operational research and public heath evaluations. 

African Cohort Study (AFRICOS)

In 2013, MHRP initiated a large, long-term cohort study at multiple African sites that evaluates HIV prevention and treatment services it supports through local facilities, funded by the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR). Named the African Cohort Study (AFRICOS), the study—the first of its kind in sub-Saharan Africa—is taking place at sites in Kenya, Nigeria, Tanzania and Uganda. Find more information on AFRICOS in the research section.

Public Health Evaluations (PHEs): 

A hypothesis-driven model of research, PHEs compare one program model, approach or intervention to another and evaluate them based on expected outputs, outcomes or impacts of the program. 

MHRP’s Kenya program began its first PHE in 2010, called the “Clic-based ART Diagnostic Evaluation Study,” or CLADE. It is an unblinded, randomized prospective, observational, cohort public health evaluation aimed at determining the superiority and cost-effectiveness of two recommended Ministry of Health ART diagnostic evaluation approaches: routine care and viral load guided care. CLADE is unique in that it addresses critical monitoring questions at the actual clinic level and includes actual costs for cost-effectiveness evaluations as a primary study objective. 

Implementation Science

MHRP's Global Health Programs is expanding its implementation science program, which aims to identify novel ways to implement health systems. Several studies will begin in 2015 including one focused on Fisher-folk in Uganda, a peer-to-peer program for PMTCT and the roll-out of a new electronic patient follow up system in Kenya and Tanzania.

Basic Program Evaluations (BPEs)

MHRP conducts several of these studies that focus on operational research to inform program quality and provide mid-course corrections and improvements for a project. The research identifies promising models or best practices for expansion within the program, and indicates whether a specific program model accomplishes its goals.  

For more information on U.S.-based research, please visit our Research section.