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M. Gordon Joyce, B.Sc. (Hons), Ph.D.

Chief, Structural Biology

Dr. M. Gordon Joyce received a B.Sc. (Hons) in Biochemistry from the National University of Ireland, Galway in 2001, followed by a Ph.D. in Structural Biology from the University of Leicester in 2006. He then began work on the structural characterization of human immunoreceptors with Dr. Peter Sun in the Laboratory of Immunogenetics at NIH. In 2011, he moved to the NIH’s Vaccine Research Center working with Dr. Gary Nabel, Dr. Peter Kwong and Dr. John Mascola on the structure-based design of HIV-1, Influenza and RSV vaccine candidates. Most recently, he has been involved in the study of understanding the induction and prevalence of broadly protective antibodies in humans following infection or vaccination. Dr. Joyce is an author of over 50 peer-reviewed manuscripts and a co-inventor on 7 patents describing vaccine immunogens and monoclonal antibody therapeutics for HIV-1, Influenza, RSV, and MERS.

Antibodies with protective activity are thought to be a critical component of an effective HIV vaccine. Characterization of B cell and virus co-evolution in patients, has informed our understanding of antibody development. In order to counteract HIV-1 viral diversity, broadly neutralizing antibodies precisely target specific sites of vulnerability. Structure-based vaccine design allows the development of novel immunogens that can target the induction and development of specific antibodies targeted to neutralization-sensitive supersites. The Joyce lab studies the interplay between HIV Env structure and function including Env sequence diversity, glycan shielding and structural malleability and how this information can be used to develop novel Env-based immunogens capable of eliciting broadly protective antibodies.

Selected Publications

M. Gordon Joyce, Zhang B, Ou L, Chen M, Chuang GY, Druz A, Kong WP, Lai YT, Rundlet EJ, Tsybovsky Y, Yang Y, Georgiev IS, Guttman M, Lees R, Pancera M, Sastry M, Soto C, Stewart-Jones GBE, Thomas PV, Van Galen JG, Baxa U, Lee KK, Mascola JR, Graham BS, Kwong PD. (2016) Iterative structure-based improvement of a fusion glycoprotein vaccine against respiratory syncytial virus. Nat. Struct. Mol. Biol. 23:811-820. PMID: 27478931

M. Gordon Joyce, Wheatley AK, Thomas PV, Chuang GY, Soto C, Bailer RT, Boyington JC, Druz A, Kanekiyo M, Kong WP, Lees CR, Leung K, Narpala SN, Prabhakaran MS, Soto C, Whittle JR, Yassine HM, Zhang B, Zhang Y, Tsybovsky Y, Baxa U, Graham BS, Koup RA, Ledgerwood JE, Roederer M, Kwong PD, Mascola JR, McDermott AB. (2016) Discovery of Vaccine-Induced Antibodies  that Neutralize Group 1 and 2 Influenza A Viruses. Cell. 166:609-623. PMID: 27453470

Bonsignori M, Zhou T, Sheng Z, Chen L, Gao F, M. Gordon Joyce, Ozorowski G, Chuang GY, Schramm CA, Wiehe K, Alam SM, Bradley T, Gladden MA, Hwang KK, Iyengar S, Kumar A, Lu X, Luo K, Mangiapani MC, Parks RJ, Song H, Acharya P, Bailer RT, Cao A, Druz A, Georgiev IS, Kwon YD, Louder MK, Zhang B, Zheng A, Hill BJ, Kong R, Soto C, NISC Comparative Sequencing Program, Mullikin JC, Douek DC, Montefiori DC, Moody MA, Shaw GM, Hahn BH, Kelsoe G, Hraber PT, Korber BT, Boyd SD, Fire AZ, Kepler TB, Shapiro L, Ward AB, Mascola JR, Liao HX, Kwong PD, Haynes BF. (2016) Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimicking Antibody. Cell. 165:449-463. PMID: 26949186

Davenport TM, Gorman J, M. Gordon Joyce, Zhou T, Soto C, Guttman M, Moquin S, Yang Y,  Zhang B, Doria-Rose NA, Hu SL, Mascola JR, Kwong PD, Lee KL. (2016) Somatic Hypermutation-Induced Changes in the Structure and Dynamics of HIV-1 Broadly Neutralizing Antibodies. Structure. 24:1346-1357. PMID: 27299673

Wang L, Shi W, M. Gordon Joyce, Modjarrad K, Zhang Y, Leung K, Lees CR, Zhou T, Yassine HM, Kanekiyo M, Yang ZY, Chen X, Becker MM, Freeman MC, Vogel L, Johnson JC, Olinger G, Todd JP, Bagci U, Solomon J, Mollura DJ, Hensley L, Jahrling P, Denison MR, Rao S, Subbarao K, Kwong PD, Mascola JR, Kong WP, Graham BS. (2015) Evaluation of candidate vaccine approaches for MERS-CoV. Nature Comm. 6:7712. PMID: 26218507

Doria-Rose NA, M. Gordon Joyce. (2015) Strategies to guide the antibody affinity maturation process. Curr Opin Virology. 11:137-147. PMID: 25913818

All publications