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Morgane Rolland, Ph.D.

Chief, Viral Genetics Section & Systems Serology Core

 

Biography

Dr. Morgane Rolland received her Ph.D. from the University of Bordeaux, France in 2003. She completed a post-doctoral fellowship with Professor James I. Mullins in the Microbiology department of the University of Washington in Seattle between 2004 and 2010.

Research

Dr. Rolland is interested in better understanding the infectious disease dynamics of emerging human viral pathogens, in particular HIV-1, and translating this knowledge to develop vaccines. The Rolland Lab analyzes molecular sequence data to infer evolutionary and population dynamic processes, while also integrating structural bioinformatics to the analysis of pathogen sequences. Our studies aim to characterize the interplay between evolutionary dynamics and the host immune pressure in the context of natural infection or following vaccination. 

The Rolland Lab has pioneered sieve analyses methods, aiding understanding of the genetic consequences of vaccine-induced immune responses in breakthrough infections, thereby providing insights on potential mechanisms of vaccine protection or on risks for future vaccine resistance.

The fact that vaccine efficacy was seen in the absence of high titers of neutralizing antibodies in the context of HIV-1 or Dengue vaccination led us to develop a systems serology platform allowing us to profile Fc-antibody function biophysically and functionally. With this approach, the lab integrates data from different immunological assays generated by the Rolland group and other MHRP labs using machine learning methods to provide a systems-level understanding of antibody function beyond neutralization.

Dr Rolland’s group includes scientists with expertise in evolutionary biology, population genetics, structural bioinformatics, immunology, mathematical modeling and statistics. Meet scientists from the Rolland lab here.

Research topics include:

Acute/Early HIV-1 infection

Follow-up of high-risk volunteers in the RV217/ECHO cohort allows us to understand HIV-1 transmission, its adaptation to new hosts, and the development of immune escape.

Breakthrough HIV-1 infections in vaccine trials

The analysis of HIV-1 breakthrough infections allows to understand the genetic consequences of vaccine-induced immune responses and can provide insights on potential mechanisms of vaccine protection.

HIV-1 vaccine design

Harnessing aspects of HIV-1 dynamics and evolution to develop better HIV-1 vaccine candidates.

Selected Publications

  • Janes H, Herbeck JT, Tovanabutra S, Thomas R, Frahm N, Duerr A, Hural J, Corey L, Self SG, Buchbinder SP, McElrath MJ, O'Connell RJ, Paris RM, Rerks-Ngarm S, Nitayaphan S, Pitisuttihum P, Kaewkungwal J, Robb ML, Michael NL, Mullins JI, Kim JH, Gilbert PB, Rolland M. HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders. 2015. Nature Medicine.
     
  • Rolland M., Edlefsen PT., Larsen BB., Tovanabutra S., Sanders-Buell E., Hertz T., DeCamp AC., Carrico C., MenisS., Magaret CA., Ahmed H., Juraska M., Chen L., Konopa P., Nariya S., Stoddard JN., Wong K., Zhao H., Deng W., Maust BS., Bose M., Howell S., Bates A., Lazzaro M., O'Sullivan A., Lei E., Bradfield A., Ibitamuno G., Assawadarachai V., O'Connell RJ., DeSouza MS., Nitayaphan S., Rerks-Ngarm S., Robb ML., McLellan JS., Georgiev I.,Kwong PD., Carlson JM., Michael NL., Schief WR., Gilbert PB., Mullins JI., Kim JH. Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2. Nature.
     
  • Rolland M., Tovanabutra S., deCamp A.C., Frahm N., Gilbert P.B., Sanders-Buell E., Heath L., Magaret C., Bose M., Bradfield A., O’Sullivan A., Crossler J., Jones T., Nau M., Wong K., Zhao H., Raugi D.N., Sorensen S., Stoddard J.N., Maust B.S., Deng W., Hural J., Dubey S., Michael N.L., Shiver J., Corey L., Li F., Self S.G., Kim J., Buchbinder S., Casimiro D.R., Robertson M.L., Duerr A., McElrath M.J., McCutchan F.E., and Mullins J.I. Genetic impact of vaccination on breakthrough HIV-1 sequences from the Step trial. 2011. Nature Medicine.
     
  • Herbeck J.T., Rolland M., Liu Y., McLaughlin S., McNevin J., Zhao H., Wong K., Stoddard J.N., Raugi D.N., Sorensen S., Genowati I., Birditt B., McKay A., Diem K., Maust B.S., Deng W., Collier A.C., Stekler J.D., McElrath M.J., and Mullins J.I. Demographic processes affect HIV-1 evolution in primary infection before the onset of selective processes. 2011. Journal of Virology.
     
  • Rolland M., Nickle D.C., Mullins J.I. HIV-1 group M Conserved Elements vaccine. 2007. PLoS Pathogens

Complete list of published work in MyBibliography