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June 19, 2018
HIV Viral Load Rebounds Rapidly After Treatment Interruption in Individuals Who Begin ART During Fiebig I
HIV viral load rebounds rapidly despite suppressive antiretroviral therapy (ART) initiated at the earliest stage of infection before seroconversion. These findings were reported in the journal Nature Medicine by researchers at MHRP and SEARCH Thailand.
HIV latent reservoirs can hide from the immune system and pose a major obstacle to HIV remission. HIV remission is the ability to...
May 23, 2018
New HIV Cohort Study Opens In Germany
This week MHRP and collaborators at the Institute for HIV Research, University Duisburg-Essen launched a longitudinal cohort study in Germany to evaluate the incidence of HIV subtype B among an at-risk subpopulation and determine the feasibility of conducting an HIV vaccine efficacy trial there in the future. In addition, the study is the largest systematic epidemiological study for sexual...
May 17, 2018
Biomarker Signatures in Acute HIV Infection Associate with Viral Dynamics and Reservoir Size
Distinct biomarker signatures arising during acute HIV infection appear to be associated with the establishment and persistence of the viral reservoir, according to findings from a new study from MHRP published today in JCI Insight.
The viral reservoir poses a challenge in the quest to cure HIV infection since it contains cells in which HIV can lie dormant for many years, thereby...
May 16, 2018
Navigating the Path to an HIV Vaccine
In medical research, the breakthroughs get all the glory. Discoveries of new germs, vaccines and wonder drugs win scientists attention from the media and mentions in history books, building an illusion that medical progress leapfrogs from one “eureka moment” to the next.
But in reality, science is an arduous journey, an incremental process of inquiry and experimentation carried out by...
May 15, 2018
Announcing Dr. Sandhya Vasan as MHRP's Associate Director for HIV Vaccine Research
Dr. Sandhya Vasan will be relocating to the United States in July to become MHRP's Associate Director for HIV Vaccine Research, a new position within the program.
From 2011 – 2018, Dr. Vasan worked for MHRP in the Department of Retrovirology of the Armed Forces Research Institute of Medical Sciences (AFRIMS) in Bangkok, Thailand to conduct preventative vaccine trials in follow-up to the...
May 3, 2018
Dr. Robert Gramzinski Named as New Director of MHRP
Dr. Robert Gramzinski has been named as the new Director of the U.S. Military HIV Research Program (MHRP) at the Walter Reed Army Institute of Research (WRAIR), stepping into a role vacated by COL Nelson Michael, who is retiring from the U.S. Army.
Dr. Gramzinski has had a distinguished career serving at WRAIR and MHRP in several roles for the last 10 years, most recently as the HIV...
March 23, 2018
RNA Signatures of Natural Killer Immune Cells Suggest Increased Activity Following HIV Vaccination
Natural killer (NK) cells are able to kill virus-infected or transformed cells and represent an important component of the human immune system. In a new study led by MHRP, researchers utilized cell sorting and transcriptional profiling to identify unique RNA transcription signatures to help unveil the potential mechanisms through which NK cells respond to HIV infection and vaccination....
March 8, 2018
DREAMS Work in Mbeya Provides a Path Out of Prostitution
Joyce was just 12 years old when her parents divorced, leaving her mother to raise her and her three siblings in a village near Mbeya, Tanzania. Without land to farm or a proper income, Joyce’s mother struggled to put food on the table. Joyce, a promising secondary school student, did her best to help her mother, but soon they couldn’t afford school uniforms or books for the children.
...
March 2, 2018
MHRP Scientists and Collaborators Presenting at CROI 2018
MHRP and collaborators will give the following presentations at the annual Conference on Retroviruses and Opportunistic Infections (CROI) taking place March 4-7 in Boston (bolded presentations are given by MHRP researchers):
Monday, March 5
Sandhya Vasan*: Session moderator, "Virus and Host Determinants of HIV Pathogenesis"
Rapee Trichavaroj: "HIV serology following...
January 24, 2018
Study Links Gut-Homing Protein Levels With HIV Infection Risk, Disease Progression
A new study has shown a relationship between the levels of a gut-homing protein called alpha-4 beta-7 occurring at the time of HIV infection and health outcomes in people. The study, led by researchers at the Centre for the AIDS Programme of Research in South Africa (CAPRISA), was published this week in Science Translational Medicine.
Gut-specific homing is the mechanism by which...