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August 28, 2019
New Sequencing Study Provides Insight into HIV Vaccine Protection
In a new study, scientists led by MHRP identified a transcriptional signature in B cells associated with protection from SIV or HIV infection in five independent trials of HIV-1 vaccine candidates. The gene expression signature was found to correlate with protection in the only human HIV vaccine trial that previously showed modest efficacy, RV144. Results from the study were published...
July 23, 2019
US Army and partners to launch HIV vaccine efficacy trial in the Americas and Europe
The U.S. Army Medical Research and Development Command (USAMRDC) is part of a global partnership preparing to launch Mosaico, the first large-scale Phase 3 efficacy study of an investigational mosaic-based HIV-1 preventive vaccine. This study was announced by partners last week and further details about the partnership and the study have been provided at the 10th IAS Conference on HIV Science...
July 19, 2019
MHRP Scientists and Collaborators Presenting at IAS 2019
MHRP and collaborators will present the following abstracts at the IAS Conference on HIV Science (IAS 2019) taking place July 21-24 in Mexico City (bolded names are MHRP researchers):
Julie Ake (oral abstract session co-chair), HIV vaccines: Light at the end of the tunnel?
Hiroshi Takata*, "Early ART initiation in acute HIV infection generates long-lived memory HIV-specific CD8+ ...
May 15, 2019
HIV Vaccine Awareness Day 2019
For decades, volunteers, community members, health professionals and scientists have worked to fill a toolbox with methods to prevent and treat HIV/AIDS, driving down incidence of new infections and increasing the life span and quality of people living with HIV. With advancements in antiretroviral therapies and biomedical prevention options like PrEP, and other exciting innovations like long-...
April 11, 2019
MHRP Researcher Dr. Morgane Rolland on the Importance of Viral Genetics
MHRP’s Chief of Viral Genetics and Systems Serology Dr. Morgane Rolland has co-edited, together with Dr. Josh Herbeck, an edition of Current Opinion in HIV and AIDS devoted to HIV-1 phylogenetics. Dr. Rolland authored an editorial and review for the issue, focusing on how research into viral diversity can increase understanding of the epidemic and contribute to improved HIV vaccine candidates...
March 22, 2019
MHRP Scientists and Collaborators Presenting at Keystone Symposia 2019
MHRP scientists and collaborators will present the following abstracts at the Keystone Symposia on HIV Vaccines and Functional Cures and the Eradication of HIV taking place March 24-28 in Whistler, British Columbia (bolded names are MHRP researchers):
Rasmi Thomas* (workshop co-chair), "Immunology of HIV Cure"
Diane Bolton* (workshop co-chair), "T Cells in HIV Vaccination and...
March 13, 2019
Three Neutralizing Antibody Lineages Identified from an HIV-1-Infected Individual
A new longitudinal analysis illuminates early events in the development of three neutralizing antibody lineages in an HIV-1-infected individual, insights which may help inform vaccine design. Researchers, led by scientists with the U.S. Military HIV Vaccine Research Program (MHRP) at the Walter Reed Army Institute of Research and the Vaccine Research Center at the National Institutes of Health...
March 5, 2019
‘This Is What It Means to Be Empowered’
At age 15, having completed only four years of primary education, a young woman named Winnie in a small town in Uganda found work as a barmaid to help support herself and her family. Friends convinced her to take on sex work, and she eventually agreed to have unprotected sex with customers willing to pay more money.
“When I became pregnant the story changed, I wouldn’t get customers...
February 28, 2019
MHRP Scientists and Collaborators Presenting at CROI 2019
MHRP and collaborators will present the following abstracts at the annual Conference on Retroviruses and Opportunistic Infections (CROI) taking place March 4-7 in Seattle (bolded names are MHRP researchers):
Gowoon Son*, “Gender and coinfections contribute to immune activation in treated HIV infection”*
Christina Polyak, “Antiretroviral regimen durability is not driven by viral...
January 17, 2019
Landmark Acute HIV Infection Cohort Study Concludes
MHRP’s RV217, an ambitious early capture acute HIV infection cohort study led by Clinical Deputy Director Dr. Merlin Robb, concluded in late 2018 after nine years of research activity.
The study, sponsored by the Division of AIDS at the National Institute of Allergy and Infectious Diseases, began in 2009 and prospectively followed a group of high-risk volunteers in East Africa and...