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March 23, 2018
RNA Signatures of Natural Killer Immune Cells Suggest Increased Activity Following HIV Vaccination

Natural killer (NK) cells are able to kill virus-infected or transformed cells and represent an important component of the human immune system. In a new study led by MHRP, researchers utilized cell sorting and transcriptional profiling to identify unique RNA transcription signatures to help unveil the potential mechanisms through which NK cells respond to HIV infection and vaccination....

March 8, 2018
DREAMS Work in Mbeya Provides a Path Out of Prostitution

Joyce was just 12 years old when her parents divorced, leaving her mother to raise her and her three siblings in a village near Mbeya, Tanzania. Without land to farm or a proper income, Joyce’s mother struggled to put food on the table. Joyce, a promising secondary school student, did her best to help her mother, but soon they couldn’t afford school uniforms or books for the children.


March 2, 2018
MHRP Scientists and Collaborators Presenting at CROI 2018

MHRP and collaborators will give the following presentations at the annual Conference on Retroviruses and Opportunistic Infections (CROI) taking place March 4-7 in Boston (bolded presentations are given by MHRP researchers): 

Monday, March 5

Sandhya Vasan*: Session moderator, "Virus and Host Determinants of HIV Pathogenesis"

Rapee Trichavaroj: "HIV serology following...

January 24, 2018
Study Links Gut-Homing Protein Levels With HIV Infection Risk, Disease Progression

A new study has shown a relationship between the levels of a gut-homing protein called alpha-4 beta-7 occurring at the time of HIV infection and health outcomes in people. The study, led by researchers at the Centre for the AIDS Programme of Research in South Africa (CAPRISA), was published this week in Science Translational Medicine.

Gut-specific homing is the mechanism by which...

January 8, 2018
Experimental Vaccine Blocks Effects of Heroin in Mice

Researchers with the U.S. Military HIV Research Program at the Walter Reed Army Institute of Research (WRAIR) report that an experimental heroin vaccine induced antibodies that prevented the drug from crossing the blood-brain barrier in mice. The vaccine was co-developed by intramural scientists at National Institute on Drug Abuse (NIDA), who funded the preclinical research.


December 5, 2017
Army-developed Zika Vaccine Induces Strong Immune Response in Three Phase 1 Studies

SILVER SPRING, MD – Three Phase 1 human clinical trials evaluating an Army-developed Zika purified inactivated virus (ZPIV) vaccine have shown it was safe and well-tolerated in healthy adults and induced a robust immune response. Initial findings from the trials were published online today in The Lancet.

Each of the three studies included in the paper was designed to address a unique...

November 28, 2017
World AIDS Day 2017

Few wars are won without allies. The fight to end the HIV epidemic is no exception. To combat a virus so evasive and deadly, governments, institutions and individuals from around the world have combined efforts and resources to make headway against a disease whose impact respects no borders.

The U.S. Military HIV Research Program (MHRP) at the Walter Reed Army Institute of Research (...

November 15, 2017
Social Science Research with Acute HIV Cohort Seeks to Understand Volunteers' Perspectives

A new article published this week in the Journal of Medical Ethics reports on insights gleaned from in-depth interviews with members of an acute HIV infection cohort about their decision to participate in an HIV remission study with analytical treatment interruption.

The SEARCH10/RV254 cohort, which is headed by MHRP’s Dr. Jintanat Ananworanich, is an acute HIV cohort in Bangkok,...

November 6, 2017
MHRP Scientists and Collaborators at the ASTMH Annual Meeting

MHRP researchers and collaborators will give the following presentations at the 66th Annual ASTMH Meeting taking place November 5-9 in Baltimore: 

Tuesday, November 7 

Safety/Immunogenicity of a Single Intramuscular Dose of the Investigational Recombinant Chimpanzee Adenovirus Type 3-Vectored Ebola Zaire Vaccine (ChAd3-EBO-Z) in Children in Africa: A Phase 2, Randomized,...

September 15, 2017
Nigeria Biopreparedness Initiative Launches with Training Event and Site Assessment

Earlier this week, a multinational group of infectious disease physicians and laboratory experts, including those from Walter Reed Program-Nigeria (WRP-N) and the Nigerian Ministry of Defence’s Health Implementation Program (NMOD-HIP), visited the 68th Nigerian Army Reference Hospital in Yaba, Lagos, to assess the hospital’s capacity to handle highly contagious infectious diseases and conduct...