A new study led by the U.S. Military HIV Research Program (MHRP) has shown that active HIV reservoir that persists even during suppressive antiretroviral therapy (ART) is correlated with increased HIV-specific CD8+ T cell immune response, but prevents them from becoming fully functional. This suggests that strategies targeting the active HIV reservoir hold promise for functional “cure” therapies to bring about long-term HIV remission. Findings were published this week in Cell Host & Microbe.
MHRP in Nigeria, known locally as the Walter Reed Program-Nigeria (WRP-N), in partnership with the Nigeria Ministry of Defence Health Implementation Programme (NMODHIP), conducted a 3-day cervical cancer screening training for 28 healthcare professionals in April.
Dr. Trevor Crowell, a senior HJF clinical investigator with the U.S. Military HIV Research Program (MHRP) was awarded a three-year NIH R01 grant to leverage four MHRP cohorts to apply advanced machine learning analytic techniques to investigate COVID-19 vaccine uptake and impact on HIV and neurobehavioral outcomes.
As part of MHRP’s ongoing African Cohort Study (AFRICOS), researchers assessed the prevalence and incidence of HIV-TB among participants receiving services supported by the President’s Emergency Plan for AIDS Relief (PEPFAR) to identify factors associated with co-morbidity and better understand gaps in TB screening and diagnosis.