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2021 Publications


Komla E, Torres OB, Jalah R, Sulima A, Beck Z, Alving CR, Jacobson AE, Rice KC, Matyas GR. Effect of Preexisting Immunity to Tetanus Toxoid on the Efficacy of Tetanus Toxoid-Conjugated Heroin Vaccine in Mice. Vaccines (Basel). 2021 Jun 1;9(6):573. doi: 10.3390/vaccines9060573. PMID: 34205869.

Sei CJ, Rao M, Schuman RF, Daum LT, Matyas GR, Rikhi N, Muema K, Anderson A, Jobe O, Kroscher KA, Alving CR, Fischer GW. Conserved Influenza Hemagglutinin, Neuraminidase and Matrix Peptides Adjuvanted with ALFQ Induce Broadly Neutralizing Antibodies. Vaccines (Basel). 2021 Jun 25;9(7):698. doi: 10.3390/vaccines9070698. PMID: 34202178.

Olawore O, Crowell TA, Ketende SC, Ramadhani HO, Liu H, Ake JA, Kokogho A, Adebajo S, Charurat ME, Nowak RG, Baral SD; TRUST/RV368 Study Group. Individual and partnership characteristics associated with consistent condom use in a cohort of cisgender men who have sex with men and transgender women in Nigeria. BMC Public Health. 2021 Jun 30;21(1):1277. doi: 10.1186/s12889-021-11275-w. PMID: 34193101.

Goh OQ, Kroon E, Sacdalan C, Chan P, Crowell TA, Kanaprach R, Anonworanich J, Vasan S, Wu AW, Phanuphak N, Colby DJ. Persons living with HIV treated in acute HIV infection report good health-related quality of life in Thailand. AIDS Care. 2021 Jun 30:1-8. doi: 10.1080/09540121.2021.1944596. Online ahead of print. PMID: 34191663.

Gutman ES, Irvin TC, Morgan JB, Barrientos RC, Torres OB, Beck Z, Matyas GR, Jacobson AE, Rice KC. Synthesis and immunological effects of C14-linked 4,5-epoxymorphinan analogues as novel heroin vaccine haptens. RSC Chem Biol. 2021 Apr 19;2(3):835-842. doi: 10.1039/d1cb00029b. PMID: 34179783.

Li Y, Bai H, Sanders-Buell E, Dussupt V, Townsley S, Donofrio G, Bose M, O'Sullivan AM, Kibuuka H, Maganga L, Nitayaphan S, Kosgei J, Pitisuttithum P, Rerks-Ngarm S, Eller LA, Michael NL, Robb ML, Ake J, Vasan S, Tovanabutra S, Krebs SJ, Rolland M. Limited evidence for a relationship between HIV-1 glycan shield features in early infection and the development of neutralization breadth. J Virol. 2021 Jun 23:JVI0079721. doi: 10.1128/JVI.00797-21. Online ahead of print. PMID: 34160251.

Tunnage J, Yates A, Nwoga C, Sing'oei V, Owuoth J, Polyak CS, Crowell TA; RV393 Study Group. Hepatitis and tuberculosis testing are much less common than HIV testing among adults in Kisumu, Kenya: results from a cross-sectional assessment. BMC Public Health. 2021 Jun 15;21(1):1143. doi: 10.1186/s12889-021-11164-2. PMID: 34130663.

Paquin-Proulx D, Gunn BM, Alrubayyi A, Clark DV, Creegan M, Kim D, Kibuuka H, Millard M, Wakabi S, Eller LA, Michael NL, Schoepp RJ, Hepburn MJ, Hensley LE, Robb ML, Alter G, Eller MA. Associations Between Antibody Fc-Mediated Effector Functions and Long-Term Sequelae in Ebola Virus Survivors. Front Immunol. 2021 May 20;12:682120. doi: 10.3389/fimmu.2021.682120. eCollection 2021. PMID: 34093585.

Cai F, Chen WH, Wu W, Jones JA, Choe M, Gohain N, Shen X, LaBranche C, Eaton A, Sutherland L, Lee EM, Hernandez GE, Wu NR, Scearce R, Seaman MS, Moody MA, Santra S, Wiehe K, Tomaras GD, Wagh K, Korber B, Bonsignori M, Montefiori DC, Haynes BF, de Val N, Joyce MG, Saunders KO. Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates. PLoS Pathog. 2021 Jun 4;17(6):e1009624. doi: 10.1371/journal.ppat.1009624. Online ahead of print. PMID: 34086838.

Barrientos RC, Whalen C, Torres OB, Sulima A, Bow EW, Komla E, Beck Z, Jacobson AE, Rice KC, Matyas GR. Bivalent Conjugate Vaccine Induces Dual Immunogenic Response That Attenuates Heroin and Fentanyl Effects in Mice. Bioconjug Chem. 2021 Jun 2. doi: 10.1021/acs.bioconjchem.1c00179. Online ahead of print. PMID: 34076427.

Lu P, Guerin DJ, Lin S, Chaudhury S, Ackerman ME, Bolton DL, Wallqvist A. Immunoprofiling Correlates of Protection Against SHIV Infection in Adjuvanted HIV-1 Pox-Protein Vaccinated Rhesus Macaques. Front Immunol. 2021 May 11;12:625030. doi: 10.3389/fimmu.2021.625030. eCollection 2021. PMID: 34046030.

Vaillancourt M, Hubert A, Subra C, Boucher J, Bazié WW, Vitry J, Berrazouane S, Routy JP, Trottier S, Tremblay C, Jenabian MA, Benmoussa A, Provost P, Tessier PA, Gilbert C. Velocity Gradient Separation Reveals a New Extracellular Vesicle Population Enriched in miR-155 and Mitochondrial DNA. Pathogens. 2021 Apr 27;10(5):526. doi: 10.3390/pathogens10050526. PMID: 33925397.

Dear N, Duff E, Esber A, Parikh A, Iroezindu M, Bahemana E, Kibuuka H, Owuoth J, Maswai J, Crowell TA, Ake JA, Polyak CS. Transient reductions in HIV clinic attendance and food security during the COVID-19 pandemic for people living with HIV in four African countries. Clin Infect Dis. 2021 Apr 27:ciab379. doi: 10.1093/cid/ciab379. Online ahead of print. PMID: 33906235.

Semwogerere M, Dear N, Tunnage J, Reed D, Kibuuka H, Kiweewa F, Iroezindu M, Bahemana E, Maswai J, Owuoth J, Crowell TA, Ake JA, Polyak CS, Esber A; AFRICOS Study Group.Factors associated with sexually transmitted infections among care-seeking adults in the African Cohort Study. BMC Public Health. 2021 Apr 16;21(1):738. doi: 10.1186/s12889-021-10762-4. PMID: 33863295.

MalariaGEN, Ahouidi A, Ali M, Almagro-Garcia J, Amambua-Ngwa A, Amaratunga C, Amato R, Amenga-Etego L, Andagalu B, Anderson TJC, Andrianaranjaka V, Apinjoh T, Ariani C, Ashley EA, Auburn S, Awandare G, Ba H, Baraka V, Barry AE, Bejon P, Bertin GI, Boni MF, Borrmann S, Bousema T, Branch O, Bull PC, Busby GBJ, Chookajorn T, Chotivanich K, Claessens A, Conway D, Craig A, D'Alessandro U, Dama S, Day NP, Denis B, Diakite M, Djimdé A, Dolecek C, Dondorp AM, Drakeley C, Drury E, Duffy P, Echeverry DF, Egwang TG, Erko B, Fairhurst RM, Faiz A, Fanello CA, Fukuda MM, Gamboa D, Ghansah A, Golassa L, Goncalves S, Hamilton WL, Harrison GLA, Hart L, Henrichs C, Hien TT, Hill CA, Hodgson A, Hubbart C, Imwong M, Ishengoma DS, Jackson SA, Jacob CG, Jeffery B, Jeffreys AE, Johnson KJ, Jyothi D, Kamaliddin C, Kamau E, Kekre M, Kluczynski K, Kochakarn T, Konaté A, Kwiatkowski DP, Kyaw MP, Lim P, Lon C, Loua KM, Maïga-Ascofaré O, Malangone C, Manske M, Marfurt J, Marsh K, Mayxay M, Miles A, Miotto O, Mobegi V, Mokuolu OA, Montgomery J, Mueller I, Newton PN, Nguyen T, Nguyen TN, Noedl H, Nosten F, Noviyanti R, Nzila A, Ochola-Oyier LI, Ocholla H, Oduro A, Omedo I, Onyamboko MA, Ouedraogo JB, Oyebola K, Pearson RD, Peshu N, Phyo AP, Plowe CV, Price RN, Pukrittayakamee S, Randrianarivelojosia M, Rayner JC, Ringwald P, Rockett KA, Rowlands K, Ruiz L, Saunders D, Shayo A, Siba P, Simpson VJ, Stalker J, Su XZ, Sutherland C, Takala-Harrison S, Tavul L, Thathy V, Tshefu A, Verra F, Vinetz J, Wellems TE, Wendler J, White NJ, Wright I, Yavo W, Ye H. An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples. Wellcome Open Res. 2021 Feb 24;6:42. doi: 10.12688/wellcomeopenres.16168.1. eCollection 2021.PMID: 33824913.

Sing'oei V, Ochola J, Owuoth J, Otieno J, Rono E, Andagalu B, Otieno L, Nwoga C, Copeland NK, Lawlor J, Yates A, Imbach M, Crowell TA, Eller LA, Kamau E, Modjarrad K, Cowden J, Ake J, Robb ML, Polyak CS. Clinical laboratory reference values in adults in Kisumu County, Western Kenya; hematology, chemistry and CD4. PLoS One. 2021 Mar 30;16(3):e0249259. doi: 10.1371/journal.pone.0249259. eCollection 2021. PMID: 33784358.

Rolland M, Gilbert PB. Sieve analysis to understand how SARS-CoV-2 diversity can impact vaccine protection. PLoS Pathog. 2021 Mar 25;17(3):e1009406. doi: 10.1371/journal.ppat.1009406. eCollection 2021 Mar. PMID: 33765086.

Chan P, Colby DJ, Kroon E, Sacdalan C, Pinyakorn S, Paul R, Robb M, Valcour V, Ananworanich J, Marra C, Spudich S. Clinical and laboratory impact of concomitant syphilis infection during acute HIV. HIV Med. 2021 Mar 17. doi: 10.1111/hiv.13079. Online ahead of print. PMID: 33728759.

Jones MU, Esber AL, Dear N, Bahemana E, Kibuuka H, Iroezindu M, Maswai J, Owuoth J, Polyak CS, Ake JA, Crowell TA, Hickey PW; African Cohort Study (AFRICOS) Team. The pregnancy factor: the prevalence of depression among women living with HIV enrolled in the African Cohort Study (AFRICOS) by pregnancy status. Arch Womens Ment Health. 2021 Mar 8. doi: 10.1007/s00737-021-01117-4. Online ahead of print. PMID: 33683462.

MalariaGEN, Ahouidi A, Ali M, Almagro-Garcia J, Amambua-Ngwa A, Amaratunga C, Amato R, Amenga-Etego L, Andagalu B, Anderson TJC, Andrianaranjaka V, Apinjoh T, Ariani C, Ashley EA, Auburn S, Awandare G, Ba H, Baraka V, Barry AE, Bejon P, Bertin GI, Boni MF, Borrmann S, Bousema T, Branch O, Bull PC, Busby GBJ, Chookajorn T, Chotivanich K, Claessens A, Conway D, Craig A, D'Alessandro U, Dama S, Day NP, Denis B, Diakite M, Djimdé A, Dolecek C, Dondorp AM, Drakeley C, Drury E, Duffy P, Echeverry DF, Egwang TG, Erko B, Fairhurst RM, Faiz A, Fanello CA, Fukuda MM, Gamboa D, Ghansah A, Golassa L, Goncalves S, Hamilton WL, Harrison GLA, Hart L, Henrichs C, Hien TT, Hill CA, Hodgson A, Hubbart C, Imwong M, Ishengoma DS, Jackson SA, Jacob CG, Jeffery B, Jeffreys AE, Johnson KJ, Jyothi D, Kamaliddin C, Kamau E, Kekre M, Kluczynski K, Kochakarn T, Konaté A, Kwiatkowski DP, Kyaw MP, Lim P, Lon C, Loua KM, Maïga-Ascofaré O, Malangone C, Manske M, Marfurt J, Marsh K, Mayxay M, Miles A, Miotto O, Mobegi V, Mokuolu OA, Montgomery J, Mueller I, Newton PN, Nguyen T, Nguyen TN, Noedl H, Nosten F, Noviyanti R, Nzila A, Ochola-Oyier LI, Ocholla H, Oduro A, Omedo I, Onyamboko MA, Ouedraogo JB, Oyebola K, Pearson RD, Peshu N, Phyo AP, Plowe CV, Price RN, Pukrittayakamee S, Randrianarivelojosia M, Rayner JC, Ringwald P, Rockett KA, Rowlands K, Ruiz L, Saunders D, Shayo A, Siba P, Simpson VJ, Stalker J, Su XZ, Sutherland C, Takala-Harrison S, Tavul L, Thathy V, Tshefu A, Verra F, Vinetz J, Wellems TE, Wendler J, White NJ, Wright I, Yavo W, Ye H. An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples. Wellcome Open Res. 2021 Feb 24;6:42. doi: 10.12688/wellcomeopenres.16168.1. eCollection 2021. PMID: 33824913.

Dussupt V, Modjarrad K, Krebs SJ. Landscape of Monoclonal Antibodies Targeting Zika and Dengue: Therapeutic Solutions and Critical Insights for Vaccine Development. Front Immunol. 2021 Feb 4;11:621043. doi: 10.3389/fimmu.2020.621043. eCollection 2020. PMID: 33664734.

Livingstone MC, Bitzer AA, Giri A, Luo K, Sankhala RS, Choe M, Zou X, Dennison SM, Li Y, Washington W, Ngauy V, Tomaras GD, Joyce MG, Batchelor AH, Dutta S. In vitro and in vivo inhibition of malaria parasite infection by monoclonal antibodies against Plasmodium falciparum circumsporozoite protein (CSP). Sci Rep. 2021 Mar 5;11(1):5318. doi: 10.1038/s41598-021-84622-x. PMID: 33674699.

Townsley SM, Donofrio GC, Jian N, Leggat DJ, Dussupt V, Mendez-Rivera L, Eller LA, Cofer L, Choe M, Ehrenberg PK, Geretz A, Gift S, Grande R, Lee A, Peterson C, Piechowiak MB, Slike BM, Tran U, Joyce MG, Georgiev IS, Rolland M, Thomas R, Tovanabutra S, Doria-Rose NA, Polonis VR, Mascola JR, McDermott AB, Michael NL, Robb ML, Krebs SJ. B cell engagement with HIV-1 founder virus envelope predicts development of broadly neutralizing antibodies. Cell Host Microbe. 2021 Feb 26:S1931-3128(21)00046-9. doi: 10.1016/j.chom.2021.01.016. Online ahead of print. PMID: 33662277.

Karch CP, Burkhard P, Matyas GR, Beck Z. The diversity of HIV-1 fights against vaccine efficacy: how self-assembling protein nanoparticle technology may fight back. Nanomedicine (Lond). 2021 Mar 10. doi: 10.2217/nnm-2020-0450. Online ahead of print. PMID: 33715403.

Bright B, Babalola CP, Sam-Agudu NA, Onyeaghala AA, Olatunji A, Aduh U, Sobande PO, Crowell TA, Tebeje YK, Phillip S, Ndembi N, Folayan MO. COVID-19 preparedness: capacity to manufacture vaccines, therapeutics and diagnostics in sub-Saharan Africa. Global Health. 2021 Mar 3;17(1):24. doi: 10.1186/s12992-021-00668-6. PMID: 33658050.

Hsu DC, Schuetz A, Imerbsin R, Silsorn D, Pegu A, Inthawong D, Sopanaporn J, Visudhiphan P, Chuenarom W, Keawboon B, Shi W, Robb ML, Mascola JR, Geleziunas R, Koup RA, Barouch DH, Michael NL, Vasan S. TLR7 agonist, N6-LS and PGT121 delayed viral rebound in SHIV-infected macaques after antiretroviral therapy interruption. PLoS Pathog. 2021 Feb 18;17(2):e1009339. doi: 10.1371/journal.ppat.1009339. Online ahead of print. PMID: 33600506.

Lima NS, Moon D, Darko S, De La Barrera RA, Lin L, Koren MA, Jarman RG, Eckels KH, Thomas SJ, Michael NL, Modjarrad K, Douek DC, Trautmann L. Pre-existing Immunity to Japanese Encephalitis Virus Alters CD4 T Cell Responses to Zika Virus Inactivated Vaccine. Front Immunol. 2021 Feb 24;12:640190. doi: 10.3389/fimmu.2021.640190. eCollection 2021. PMID: 33717194.

Tola M, Habib RO, Sylvia A, Crowell TA, Rebecca NG, Charurat ME, Dakum P, Ndembi N. Field evaluation of HIV-1 viral load monitoring in adults and children receiving antiretroviral treatment in Nigeria by dried blood spot testing with RealTime HIV-1 on m2000. J Clin Virol. 2021 Feb;135:104694. doi: 10.1016/j.jcv.2020.104694. Epub 2020 Nov 25. PMID: 33476928.

Silva de Castro I, Gorini G, Mason R, Gorman J, Bissa M, Rahman MA, Arakelyan A, Kalisz I, Whitney S, Becerra-Flores M, Ni E, Peachman K, Trinh HV, Read M, Liu MH, Van Ryk D, Paquin-Proulx D, Shubin Z, Tuyishime M, Peele J, Ahmadi MS, Verardi R, Hill J, Beddall M, Nguyen R, Stamos JD, Fujikawa D, Min S, Schifanella L, Vaccari M, Galli V, Doster MN, Liyanage NPM, Sarkis S, Caccuri F, LaBranche C, Montefiori DC, Tomaras GD, Shen X, Rosati M, Felber BK, Pavlakis GN, Venzon DJ, Magnanelli W, Breed M, Kramer J, Keele BF, Eller MA, Cicala C, Arthos J, Ferrari G, Margolis L, Robert-Guroff M, Kwong PD, Roederer M, Rao M, Cardozo TJ, Franchini G. Anti-V2 antibodies virus vulnerability revealed by envelope V1 deletion in HIV vaccine candidates. iScience. 2021 Jan 9;24(2):102047. doi: 10.1016/j.isci.2021.102047. eCollection 2021 Feb 19. PMID: 33554060.

Dearlove B, Tovanabutra S, Owen CL, Lewitus E, Li Y, Sanders-Buell E, Bose M, O'Sullivan AM, Kijak G, Miller S, Poltavee K, Lee J, Bonar L, Harbolick E, Ahani B, Pham P, Kibuuka H, Maganga L, Nitayaphan S, Sawe FK, Kim JH, Eller LA, Vasan S, Gramzinski R, Michael NL, Robb ML, Rolland M; RV217 Study Team. Factors influencing estimates of HIV-1 infection timing using BEAST. PLoS Comput Biol. 2021 Feb 1;17(2):e1008537. doi: 10.1371/journal.pcbi.1008537. Online ahead of print. PMID: 33524022.

Muccini C, Crowell TA, Pinyakorn S, Kroon E, Sacdalan C, Ananworanich J, Vasan S, Phanuphak N, Colby DJ; RV254 Study Group. Brief Report: Syphilis Incidence and Effect on Viral Load, CD4, and CD4/CD8 Ratio in a Thai Cohort of Predominantly Men Who Have Sex With Men Living With HIV. J Acquir Immune Defic Syndr. 2021 Feb 1;86(2):219-223. doi: 10.1097/QAI.0000000000002542. PMID: 33433124.

Schneider CG, Taylor JA, Sibilo MQ, Miura K, Mallory KL, Mann C, Karch C, Beck Z, Matyas GR, Long CA, Bergmann-Leitner E, Burkhard P, Angov E. Orientation of Antigen Display on Self-Assembling Protein Nanoparticles Influences Immunogenicity. Vaccines (Basel). 2021 Jan 29;9(2):103. doi: 10.3390/vaccines9020103. PMID: 33572803.

Crowell TA, Fast PE, Bekker LG, Sanders EJ. Response to: "Inclusion as Illusion: Erasing Transgender Women in Research with MSM". J Int AIDS Soc. 2021 Jan;24(1):e25662. doi: 10.1002/jia2.25662. PMID: 33496371.

Garcia-Bates TM, Palma ML, Anderko RR, Hsu DC, Ananworanich J, Korber BT, Gaiha GD, Phanuphak N, Thomas R, Tovanabutra S, Walker BD, Mellors JW, Piazza PA, Kroon E, Riddler SA, Michael NL, Rinaldo CR, Mailliard RB; I4C and RV254 Study Groups. Dendritic cells focus CTL responses toward highly conserved and topologically important HIV-1 epitopes. EBioMedicine. 2021 Jan 12;63:103175. doi: 10.1016/j.ebiom.2020.103175. Online ahead of print. PMID: 33450518.

Lee EH, Ganesan K, Khamadi SA, Meribe SC, Njeru D, Adamu Y, Magala F, Crowell TA, Akom E, Agaba P, Desai P, Hamm T, Teyhen D, Ake JA, Polyak CS, Shaffer D, Sawe F, Hickey PW. Attaining 95-95-95 through Implementation Science: 15 Years of Insights and Best Practices from the Walter Reed Army Institute of Research's Implementation of the U.S. President's Emergency Plan for AIDS Relief. Am J Trop Med Hyg. 2021 Jan;104(1):12-25. doi: 10.4269/ajtmh.20-0541. PMID: 33241783.